intem ct rotem based anticoagulation management  (Rotem Industries)

Journal: Die Anaesthesiologie

Article Title: A clotting time longer than 226 s in the INTEM channel of the thromboelastometer is an independent risk factor for mortality during bleeding

doi: 10.1007/s00101-025-01602-w

Figure Lengend Snippet: CT INTEM (clotting time) and ROC analysis for mortality ( left graph ). Box and whisker plot with the 10th and 90th percentiles ( right graph ). Solid line in the box: median values of CT INTEM . The plus symbol in the box: mean values of CT INTEM . Blue line : optimal threshold for CT INTEM in prediction of 30-day mortality. Receiver operating characteristic curves (ROC) were constructed (C-statistic) to evaluate the predictive power of CT INTEM for 30-day mortality. AUC area-under-the-curve. The Youden Index was used to calculate optimal threshold for CT INTEM in prediction of 30-day mortality. Data were collected in real-time by the attending physician or nurse in parallel to the patient treatment. Each patient was considered only once. If more than one Rotem (rotational thromboelastometry) analysis was done in one patient, only the first Rotem analysis was considered

Article Snippet: Die C‐Statistik zeigte, dass CT INTEM (C-Statistik = 0,62, optimaler Schwellenwert > 226 s) prädiktiv für die 30-Tage-Sterblichkeit war.

Techniques: Coagulation, Whisker Assay, Construct

Journal: Die Anaesthesiologie

Article Title: A clotting time longer than 226 s in the INTEM channel of the thromboelastometer is an independent risk factor for mortality during bleeding

doi: 10.1007/s00101-025-01602-w

Figure Lengend Snippet: All patients ( n = 2197) and subgroups analyses in patients with ( n = 823) or without ( n = 1374) cardiopulmonary bypass. Kaplan-Meier survival plots for terciles of clotting time (CT INTEM ), CT INTEM > 226 s versus CT INTEM ≤ 226s for 30 days follow-up. ROTEM rotational thromboelastometry, CPB cardiopulmonary bypass

Article Snippet: Die C‐Statistik zeigte, dass CT INTEM (C-Statistik = 0,62, optimaler Schwellenwert > 226 s) prädiktiv für die 30-Tage-Sterblichkeit war.

Techniques: Coagulation

Journal: Thrombosis Update

Article Title: Applications of rotational thromboelastometry in heparin monitoring in critical COVID-19 disease: Observations in the Maastricht Intensive Care COVID cohort

doi: 10.1016/j.tru.2023.100140

Figure Lengend Snippet: Flowchart UFH = unfractionated heparin, LMWH = low molecular weight heparin, ROTEM = rotational thromboelastometry.

Article Snippet: The presented observations suggest a more in vivo representation of the UFH-anticoagulant effect using the ROTEM INTEM/HEPTEM CT ratio compared to the anti-Xa assay.

Techniques: Molecular Weight

Journal: Thrombosis Update

Article Title: Applications of rotational thromboelastometry in heparin monitoring in critical COVID-19 disease: Observations in the Maastricht Intensive Care COVID cohort

doi: 10.1016/j.tru.2023.100140

Figure Lengend Snippet: INTEM/HEPTEM CT ratio, aPTT, and anti-Xa values for the first available ROTEM measurement after the start of unfractionated heparin (UFH) or therapeutic low molecular weight heparin (LMWH).

Article Snippet: The presented observations suggest a more in vivo representation of the UFH-anticoagulant effect using the ROTEM INTEM/HEPTEM CT ratio compared to the anti-Xa assay.

Techniques: Molecular Weight

Journal: Thrombosis Update

Article Title: Applications of rotational thromboelastometry in heparin monitoring in critical COVID-19 disease: Observations in the Maastricht Intensive Care COVID cohort

doi: 10.1016/j.tru.2023.100140

Figure Lengend Snippet: Spearman ρ between ROTEM parameters and platelet count stratified by UFH and therapeutic LMWH.

Article Snippet: The presented observations suggest a more in vivo representation of the UFH-anticoagulant effect using the ROTEM INTEM/HEPTEM CT ratio compared to the anti-Xa assay.

Techniques:

Journal: Thrombosis Update

Article Title: Applications of rotational thromboelastometry in heparin monitoring in critical COVID-19 disease: Observations in the Maastricht Intensive Care COVID cohort

doi: 10.1016/j.tru.2023.100140

Figure Lengend Snippet: Associations between coagulation assays (aPTT and anti-Xa) and the INTEM/HEPTEM CT ratio and interaction with UFH/LMWH. When applicable, stratified analyses were performed on patients using UFH and LMWH separately.

Article Snippet: The presented observations suggest a more in vivo representation of the UFH-anticoagulant effect using the ROTEM INTEM/HEPTEM CT ratio compared to the anti-Xa assay.

Techniques: Coagulation